Book Pages

Publications (2005-2009)


  1. Wu Z.Y., Liu Q., Liang X., Yang X., Wang N.Y., Wang X.H., Sun H.Z., Lu Y., Guo Z.J. (2009) “Reactivity of platinum-based antitumor drugs towards a Met- and His-rich 20mer peptide corresponding to the N-terminal domain of human copper transporter 1Journal of Biological Inorganic Chemistry, 14(8), 1313-1323. doi: 10.1007/s00775-009-0576-7.

  2. Ding Z.C., Teng X.C., Zheng Q., Ni F.Y., Cai B., Wang Y., Zhou G.M., Sun H.Z., Tan X.S., Huang Z.X. (2009) “Important roles of the conserved linker-KKS in human neuronal growth inhibitory factorBioMetals, 22(5), 817-826. doi: 10.1007/s10534-009-9228-1.

  3. Sun X.S., Ge R.G., Chiu J.F., Sun H.Z.*, He, Q.Y.* (2009) “Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2Journal of Inorganic Biochemistry, 103(7), 1074-1081. doi: 10.1016/j.jinorgbio.2009.05.004 .

  4. Xia W., Li H.Y., Sze K.H., Sun H.Z.* (2009) “Structure of a nickel chaperone, HypA from Helicobacter pylori reveals two distinct metal binding sitesJournal of the American Chemical Society, 131(29), 10031-10040. doi: 10.1021/ja900543y.

  5. Sun X.S., Baker H.M., Ge R.G., Sun H.Z., He Q.Y., Baker E.N. (2009) “Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenesBiochemistry, 48(26), 6168-6190. doi: 10.1021/bi900552c.

  6. Cai B., Ding Z.C., Zhang Q., Ni F.Y., Wang H., Zheng Q., Wang Y., Zhou G.M., Wang K.M., Sun H.Z., Wu H.M., Huang Z.X. (2009) “The structural and biological significance of the EAAEAE insert in the α-domain of the human neuron growth inhibitory factorFEBS Journal, 276(13), 3547-3558. doi: 10.1111/j.1742-4658.2009.07075.x.

  7. Sun X.S., Tsang C.N., Sun H.Z.* (2009) “Identification and characterization of metallodrugs binding proteins by (metallo)proteomicsMetallomics, 1(1), 25-31. doi: 10.1039/B813121J. (Featured on the cover of the January issue, 2009)                                                                       

  8. He J., Hu P., Wang Y.J., Tong M.-L., Sun H.Z., Mao Z.W.* Ji L.-N. (2008) “Double-strand DNA cleavage by copper complexes of 2,2-dipyridyl with guanidinium/ammonium pendantsDalton Transactions, (24), 3207-3214. doi: 10.1039/B801549J.

  9. He J., Sun J., Mao Z.W., Ji L.N., Sun H.Z. (2009) “Phosphodiester hydrolysis and specific DNA binding and cleavage promoted by guanidinium-functionalized zinc complexesJournal of Inorganic Biochemistry, 103(5), 851-858. doi: 10.1016/j.jinorgbio.2009.02.010.

  10. Zhou Y.H., Zhao M., Sun H.Z., Mao Z.W., Ji L.N. (2009) “Effect of cyclodextrin dimers with bipyridyl and biphenyl linking groups on carboxyl ester hydrolysis catalyzed by zinc complexJournal of Molecular Catalysis A: Chemical, 308 (1-2), 61-67. doi: 10.1016/j.molcata.2009.03.026.

  11. Ge R.G., Sun H.Z. (2009) "Metallomics: An integrated biometal scienceScience in China Series B Chemistry, 52(12), 2055-2070. doi: 10.1039/B308213J.

  12. Huang J.D., Sun H.Z., Tanner J.A., Watt R.M. (2009) "Determination of the functions of the putatuve metal-binding domain of the SCV helicaseHong Kong Medical Journal, 15(Suppl 6), 15-16.


  1. Zeng Y.B., Zhang D.M., Li H.Y., Sun H.Z.* (2008) “Binding of Ni2+ to a histidine- and glutamine-rich protein, Hpn-like (Hpnl)Journal of Biological Inorganic Chemistry, 13(7), 1121-1131. doi: 10.1007/s00775-008-0397-0.

  2. Cun S.J., Li H.Y., Ge R.G., Lin M.C.M., Sun H.Z.* (2008) “A histidine- and cysteine-rich metal binding domain at the C-terminus of heat-shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibilityJournal of Biological Chemistry, 283, 15142-15151. doi: 10.1074/jbc.M800591200.

  3. Sun X.S., Ge R.G., Chiu J.F., Zu Y.B., Sun H.Z.*, He Q.-Y.* (2008) “Lipoprotein MtsA of MtsABC in Streptococus progenes primarily binds ferrous ion with bicarbonate as a synergistic anionFEBS Letter, 582(9), 1351-1354. doi: 10.1016/j.febslet.2008.03.020.

  4. Li H.Y., Gu J.D., Sun H.Z.* (2008) “Structure, topology and assembly of a 32-mer peptide corresponding to the loop 3 and transmembrane domain 4 of divalent metal transporter (DMT1) in membrane-mimetic environmentsJournal of Inorganic Biochemistry, 102(5-6), 1257-1266. doi: 10.1016/j.jinorgbio.2007.12.019.

  5. Wang H., Li H.Y., Cai B., Huang Z.X., Sun H.Z.* (2008) “The effect of nitric oxide (NO) on metal release from human metallothionein-3 (MT-3): gradual unfolding of the proteinJournal of Biological Inorganic Chemistry, 13(3), 411-419. doi: 10.1007/s00775-007-0331-x.

  6. Sun X.S., Ge R.G., Chiu J.F., Sun H.Z.*, He Q.Y.* (2008) “Identification of proteins related to nickel homeostasis in Helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresisMetal-Based Drug, 2008, 289490. doi: 10.1155/2008/289490.

  7. Huang J.D., Zheng B.J., Sun H.Z. (2008) “Helicases as antiviral drug targetsHong Kong Medical Journal, 14 Suppl 4, 36-38.

  8. Ding Z.C., Zheng Q., Cai B., Ni F.Y., Yu W.H., Teng X.C., Gao Y., Liu F., Chen D., Wang Y., Wu H.M., Sun H.Z., Zhang M.J., Tan X.S., Huang Z.X. (2008) “Study on structure-property-reactivity-function relationship of human neuronal growth inhibitory factor (hGIF)Journal of Inorganic Biochemistry, 102 (11), 1965-1972. doi: 10.1016/j.jinorgbio.2008.07.007.

  9. He J., Hu P., Wang Y.-J., Tong M.-L., Sun H.Z., Mao Z.-W., Ji L.-N. (2008) "Double-strand DNA cleavage by copper complexes of 2,2'-dipyridyl with guanidinium/ammonium pendantsDalton Transactions, 3207-3214. doi: 10.1039/B801549J.


  1. Ding Z.C., Zheng Q, Can B., Yu W.H., Teng X.C., Wang Y., Zhou G.M., Wu H.M., Sun H.Z., Zhang M.J., Huang Z.X. (2007) “Effect of α-domain substitution on the structure, property and function of human neuronal growth inhibitory factorJournal of Biological Inorganic Chemistry, 12(8), 1173-1179. doi: 10.1007/s00775-007-0287-x.

  2. Ge R.G., Sun H.Z.* (2007) “Bioinorganic chemistry of bismuth and antimony: target sites for metallodrugsAccounts of Chemical Research, 40(4), 267-274. doi: 10.1021/ar600001b.

  3. Li H.Y., Fung K.L., Jin D.Y., Chung S.S.M., Ching Y.P., Ng I.O., Sze K.H., Ko B.C.B.*, Sun H.Z.* (2007) “Solution structures, dynamics and lipid-binding of SAM domain from the deleted in liver cancer 2 (DLC2): a monomeric structure with membrane-binding propertiesPROTEINS: Structure, Function, and Bioinformatics, 67(4), 1154-1166. doi: 10.1002/prot.21361.

  4. Ni F.Y., Cai B.,  Ding Z.C., Zheng F., Zhang M.J., Wu H.M., Sun H.Z., Huang Z.X. (2007) “Structural prediction of the β-domain of metallothionein-3 by molecular dynamics simulationPROTEINS: Structure, Function, and Bioinformatics,  68(1), 255-266. doi: 10.1002/prot.21404.

  5. Wong I.L.K., Chan K.F., Burkett B.A., Zhao Y., Chai Y., Sun H.Z., Chan T.H., Chow L.M.C. (2007) “Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in LeishmaniaAntimicrobial Agents and Chemotherapy, 51(3), 930-940. doi: 10.1128/AAC.00998-06.

  6. Yang N., Sun H.Z.* (2007) “Biocoordination chemistry of bismuth: recent advancesCoordination Chemistry Reviews, 251(17-20), 2354-2366. doi: 10.1016/j.ccr.2007.03.003.

  7. Yang N., Tanner J.A., Zheng B.J., Watt R.M., He M.L., Lu L.Y., Jiang J.-Q., Shum K.-T., Lin Y.-P., Lin M.C.M., Kung H.F., Sun H.Z.*, Huang J.D.* (2007) “Bismuth complexes inhibit the SARS coronavirus” Angewandte Chemie International Edition 46(34), 6464-6468. doi: 10.1002/anie.200701021.

  8. Yang N., Tanner J.A., Wang Z., Huang J.D., Zheng B.J., Zhu N., Sun H.Z.* (2007) “Inhibition of SARS coronavirus helicase by bismuth complexesChemical Communications, (42), 4413-4415. doi: 10.1039/B709515E.

  9. Yang Z., Wang X., Diao H., Zhang J., Li H.Y., Sun H.Z., Guo Z.J. (2007) “Encapsulation of platinum anticancer drugs by apoferritinChemical Communications, (33), 3453-3455. doi: 10.1039/B705326F. (Featured on the cover of the issue on September 7, 2007)

  10. Ge R.G., Sun X.S., Gu Q., Watt R.M., Wong B.C.Y., Xia H.H.X., Huang J.D., He Q.Y.*, Sun, H.Z.* (2007) “A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pyloriJournal of Biological Inorganic Chemistry, 12(6), 831-824. doi: 10.1007/s00775-007-0237-7.

  11. Lok C.-N., Ho C.-M., Chen R., He Q.-Y., Yu W.-Y., Sun H.Z., Tam P.K.-H., Chiu J.-F., Che C.M. (2007) “Silver nanoparticles: partial oxidation and antibacterial activitiesJournal of Biological Inorganic Chemistry, 12(4), 527-534. doi: 10.1007/s00775-007-0208-z.

  12. Zhou Y.H., Fu H., Zhao W.X., Su C.Y., Sun H.Z., Ji L.N., Mao Z.W. (2007) “An effective metallohydrolase model with supramolecular environment: structures, properties and activitiesChemistry, a European Journal, 13(8), 2402-2409. doi: 10.1002/chem.200601302.

  13. Zhou Y.H., Fu H., Zhao W.X., Chen W.L., Su C.Y., Sun H.Z., Ji L.N., Mao Z.W. (2007) “Synthesis, structure, and activity of supramolecular mimics for the active site and arg141 residue of copper, zinc-superoxide dismutaseInorganic Chemistry,  46(3), 734-739. doi: 10.1021/ic061541d.

  14. An Y., Lin Y.Y., Wang H., Sun H.Z., Tong M.L., Ji L.N., Mao Z.W. (2007) “Cleavage of double-strand DNA by zinc complexes of dicationic 2,2'-dipyridyl derivatives” Journal of Chemical Society, Dalton Transactions, (12), 1250-1254. doi: 10.1039/B616754C.


  1. Ding Z.C., Teng X.C., Cai B., Wang H., Zheng Q., Wang Y., Zhou G.M., Zhang M.J., Wu H.M., Sun H.Z., Huang Z.X. (2006) “Mutation at Glu23eliminates the neuron growth inhibitory activity of human metallothionein-3Biochemical and Biophysical Research Communications, 349(2), 674-682. doi: 10.1016/j.bbrc.2006.08.090.

  2. Ge R.G., Zhang Y., Sun X.S., Watt R.M., He Q.-Y., Huang J.D., Wilcox D.E., Sun H.Z.* (2006) “Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, HpnJournal of the American Chemical Society, 128(35), 11330-11331. doi: 10.1021/ja062589t.

  3. Lok C.-N., Ho C.-M., Chen R., He Q.-Y., Yu W.-Y., Sun H.Z., Tam P.K.-H., Chiu J.-F., Che C.-M. (2006) “Proteomic analysis of the mode of antibacterial action of silver nanoparticlesJournal of Proteome Research, 5(4), 916-924. doi: 10.1021/pr0504079.

  4. Chen R., So M.H., Yang J., Deng F., Che C.-M., Sun H.Z.* (2006) “Fabrication of bismuth subcarbonate nanotube arrays from bismuth citrateChemical Communications, (21), 2265-2267. doi: 10.1039/B601764A.

  5. Cai B., Zheng Q., Teng X.C., Chen D., Wang Y., Wang K.Q., Zhou G.M., Xie Y., Zhang M.J., Sun H.Z.*, Huang Z.H. * (2006) “The Role of Thr5 in human neuron growth inhibitory factorJournal of Biological Inorganic Chemistry, 11(4), 476-482. doi: 10.1007/s00775-006-0097-6.

  6. Xue R., Wang S., Wang C.Y., Zhu T., Li, F., Sun H.Z. “HFIP-induced structures and assembly of the peptides from the transmembrane domain 4 of membrane protein, Nramp1” (2006) Biopolymers, 84(3), 329–339. doi: 10.1002/bip.20478.

  7. Wang H., Zheng Q., Cai B., Li H.Y., Sze K.H., Huang Z.X., Wu H.M., Sun H.Z.* (2006) “Solution structure and dynamics of human metallothionein-3 (MT-3)FEBS Letters, 580(3), 795-800. doi: 10.1016/j.febslet.2005.12.099.

  8. Zhang L., Mulrooney S.B.,  Leung F.K., Zeng Y.B., Ko B.C.B., Hausinger R.P.*, Sun H.Z.* (2006) “Inhibition of urease by bismuth(III): implications for the mechanism of action of bismuth drugsBioMetals, 19(5), 503-511. doi: 10.1007/s10534-005-5449-0.

  9. Ge R.G., Watt R.M., Sun X., Tanner J.A., He Q.Y., Huang J.D.*, Sun H.Z.* (2006) “Expression and characterization of a histidine-rich protein: potential for Ni2+ storage in Helicobacter pylori” Biochemical Journal 393(Pt 1), 285-293. doi: 10.1042/BJ20051160.


  1. Chai Y., Yan S.C., Wong I.L.K., Chow L.M.C., Sun H.Z.* (2005) “Complexation of antimony (SbV) with 5´-GMP and 5´-GDP-mannose: formation of both mono- and bis-adductsJournal of Inorganic Biochemistry, 99(12), 2257-2263. doi: 10.1016/j.jinorgbio.2005.08.015.

  2. Zheng B.J., Guan Y., He M.L., Sun H.Z., Du L., Zheng Y., Wong K.L., Chen H., Chen Y., Lu L., Tanner J.A., Watt R.M., Niccolai N., Bernini A., Spiga O., Woo P.C., Kung H.F., Yuen K.Y., Huang J.D. (2005) “Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirusAntiviral Therapy, 10(3), 393-403.

  3. Chen R., So M.H., Che C.-M., Sun H.Z.* (2005) “Controlled synthesis of high crystalline bismuth sulfide nanorods: using bismuth citrate as a precursorJournal of Materials Chemistry, 15(42), 4540-4545. doi: 10.1039/B510299E.

  4. Yang P.Y., Gao H.Y., Cai J.Y., Chiu J.F., Sun H.Z., He Q.-Y. (2005) “The stepwise process of chromium-induced DNA breakage: characterization by electrochemistry, atomic force microscopy and DNA electrophoresisChemical Research in Toxicology, 18(10), 1563-1566. doi: 10.1021/tx050134w.

  5. Li H.Y., Li F., Kwan M.F., He Q.-Y., Sun H.Z.* (2005) “NMR structures and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micellesBiopolymers, 77(4), 173-183. doi: 10.1002/bip.20204.

  6. Li F., Li H.Y., Kwan M.F., Hu L.H., Chen G.H., He Q.-Y., Sun H.Z.* (2005) “Structure, assembly and topology of G185R mutant of the transmembrane domain4 of divalent metal transporterJournal of the American Chemical Society, 127(5), 1414-1423. doi: 10.1021/ja047148t.

  7. Yan S.C., Jin L., Sun H.Z.* (2005) “51Sb- antimony in medicine” in ‘Metallotherapeutics Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine’ (eds. Tiekink E.R.T., Gielen M.), John Wiley & Sons, 441-461. doi: 10.1002/0470864052.ch23.

  8. Yang P.Y., Sun X. S., Chiu J.F., Sun H.Z., He Q.Y.* (2005) “Transferrin-mediated gold nanoparticle cellular uptake”. Bioconjugate Chemistry, 16(3), 494-496. doi: 10.1021/bc049775d. (Most-cited Article in 2005 in Bioconjugate Chemistry)

  9. Teng X.C., Zheng Q., Cai B., Ni F.Y., Xie Y., Sun H.Z., Zhang M.J., Huang Z.X. (2005) "An Insight of S-Nitrosylation of Human GIFChinese Journal of Chemistry, 23(11), 1545-1551. doi: 10.1002/cjoc.200591545.