Book Pages

Publications (2010-2015)


  1. Wang Y.C., Tsang C.Y., Xu F., Kong P.K., Hu L.G., Wang J.W., Chu IK, Li H.Y., Sun H.Z.* (2015) “Bio-coordination of bismuth in Helicobacter pylori revealed by immobilized metal affinity chromatographyChemical Communications, 51(92), 16479-16482. doi: 10.1039/C5CC04958J. (featured on the outside back cover)

  2. Wang M.J., Lai T-P., Wang L., Zhang H.M., Yang N., Sadler P.J., Sun H.Z.* (2015) “Anion clamp” allows flexible protein to impose coordination geometry on metal ionsChemical Communications, 51(37), 7867-7870. doi: 10.1039/C4CC09642H.

  3. Wang Y.C., Hu L.G., Yang X.M., Chang Y.Y, Hu X.Q., Li H.Y., Sun H.Z.* (2015) “On-line coupling of continuous-flow gel electrophoresis with inductively coupled plasma-mass spectrometry to quantitatively evaluate intracellular metal binding properties of metallochaperones HpHypA and HpHspA in E. coli cellsMetallomics, 7(10), 1399-1406. doi: 10.1039/c5mt00054h. (featured on the front cover of the October issue, 2015)

  4. Yang X.M., Li H.Y., Lai T.P., Sun H.Z.* (2015) “Complexation of Helicobacter pylori UreE-UreG facilitates nickel transfer and boosts GTPase activity of UreGJournal of Biological Chemistry, 290(20), 12474-12485. doi: 10.1074/jbc.M114.632364. (selected as the Paper of the Week)

  5. Lai Y.Z., Chang Y.Y., Hu L.G., Yang Y., Chao A.L., Du Z.Y., Tanner J.A., Chye M.L., Qian C.M., Ng K.M., Li H.Y., Sun H.Z.* (2015) “Rapid labeling of intracellular His-tagged proteins in living cellsProceedings of the National Academy of Sciences, USA, 112(10), 2948-2953. doi: 10.1073/pnas.1419598112.  (highlighted as a spotlight in Nat. Biotech. 2015, 33, 359, in the F1000Prime and local media). 

  6. Hong Y.F., Lai Y.T., Chan G.C.F., Sun H.Z.* (2015) “Glutathione and MRP transporter mediate a self-propelled disposal of bismuth in human cellsProceedings of the National Academy of Sciences, USA, 112(11), 3211-3216. doi: 10.1073/pnas.1421002112. (highlighted in the issue, PNAS 112(11), 3717; as a commentary in PNAS 2015, 112(14), 4187-4188, as well as a spotlight in Chem Res Toxicology, 2015, 28, 829) 

  7. Tang H.M.V., Pan K.W., Kong K.Y.E., Hu L.G., Chan L.C., Siu K.L., Sun H.Z., Wong C.M., Jin D.Y. (2015) “Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factorScientific Reports, 5, 7897, doi: 10.1038/srep07897.

  8. Chang Y.Y., Lai Y-T., Cheng T.F., Wang H.B., Yang Y., Sun H.Z.* (2015) “Selective binding of Hpnl-like protein to nickel, zinc and bismuth in vitro and in cells by FRETJournal of Inorganic Biochemistry, 142(1), 8-14. doi: 10.1016/j.jinorgbio.2014.09.010.

  9. Wang Y.C., Wang H.B., Li H.Y. Sun H.Z.* (2015) “Metallomic and metalloproteomic strategies in elucidating the molecular mechanisms of metallodrugsDalton Transaction, 43(2), 437-447. doi: 10.1039/C4DT02814G.


  1. Qin F., Zhao H., Li G., Yang H., Li J., Wang R., Liu Y., Hu J., Sun H.Z., Chen R. (2014) "Size-tunable fabrication of multifunctional Bi2O3 porous nanospheres for photocatalysis, bacteria inactivation and template-synthesisNanoscale, 6 (10), 5402-5409. doi: 10.1039/C3NR06870F.

  2. Xia W., Li H.Y., Sun H.Z.* (2014) "Functional disruption of HypB, a GTPase of Helicobacter pylori, by bismuth"Chemical Communications, 50 (13), 1611-1614. doi: 10.1039/C3CC47644H.

  3. Cun S.J., Sun H.Z.* (2014) "Urease inactivation by an unusual GroES chaperonin"Science China Chemistry, 57 (6), 842-848. doi: 10.1007/s11426-014-5088-9.

  4. Li H.Y. *, Sun H.Z.* (2014) "In-cell NMR: An emerging approach for monitoring metal-related events in living cellsMetallomics, 6 (1), 69-76. doi: 10.1039/C3MT00224A.

  5. Cheng T.F., Sun H.Z.* (2014) "Chapter 25 - Antimony and bismuthBinding, Transport and Storage of Metal Ions in Biological Cells, 2014-January (2), 768-799. doi: 10.1039/9781849739979-00768.

  6. Yang X.M., Li H.Y., Cheng T.F., Xia W., Lai Y.-T., Sun H.Z.* (2014) "Nickel translocation between metallochaperones HypA and UreE in Helicobacter pyloriMetallomics, 6 (9), 1731-1736. doi: 10.1039/c4mt00134f.

  7. Xie S., Lu Y., Jakoncic J., Sun H.Z., Xia J., Qian C.M. (2014) "Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteinsFEBS Journal, 281 (15), 3382-3396. doi: 10.1111/febs.12867.


  1. Chen W.J., Wang H.F., Ye D.R., Lin H., Sun H.Z., Zhong W.Q. (2013) “Binding of oxo-Cu2 clusters to ferric ion-binding protein A from Neisseria gonorrhoeae: a structural insightMetallomics, 5(10),  1430-1439. doi: 10.1039/C3MT00091E.

  2. Li G., Qin F., Wang R., Xiao S, Sun H.Z., Chen R. (2013) “BiOX (X=Cl, Br, I) nanostructures: mannitol-mediated microwave synthesis, visible light photocatalytic performance, and Cr(VI) removal capacityJournal of Colloid and Interface Science, 409, 43-51. doi: 10.1016/j.jcis.2013.07.068.

  3. Cun S.J., Lai Y.Z., Chang Y.Y., Sun H.Z.* (2013) “Structure-oriented bioinformatic approach exploring histidine-rich clusters in proteinsMetallomics, 5(7), 904-912. doi: 10.1039/c3mt00026e.

  4. Cheng T.F., Li H.Y., Yang X.M., Xia W., Sun H.Z.* (2013) “Interactions of SlyD with HypB of Helicobacter pylori facilitates nickel traffickingMetallomics, 5(7), 804-807. doi: 10.1039/C3MT00014A.

  5. Sun H.Z. (2013) “Metallomics in ChinaMetallomics, 5(7), 782-783. doi: 10.1039/C3MT90024J.

  6. Du X.B., Wang X.H., Li H.Y., Sun H.Z.* (2013) “Kinetics and thermodynamics of metal binding to the N-terminus of human copper transporter, hCTR1Chemical Communications, 49(80), 4134-4136. doi: 10.1039/C3CC45360J.

  7. Hu L.G., Cheng T.F., He B., Li L., Wang Y.C., Lai Y.T., Jiang G.B., Sun H.Z.* (2013) “Identification of metal-associated proteins in cells by using continuous-flow gel electrophoresis and inductively coupled plasma mass spectrometryAngewandte Chemie International Edition, 52(18), 4916-4920. doi: 10.1002/anie.201300794.

  8. Yang X.M., Xu D.C., Cheng T.F., Xi Z.Y., Zhao L.H., Liu Y.Z.*, Sun H.Z.* (2013) “Recent progress of copper and nickel chaperonesProgress in Chemistry, 25(4), 495-510. 

  9. Wang X.H., Sun H.Z.* (2013) “3.39- Metal complexes in the treatment of tropical diseases: malaria, trypanosomiasis and leishmaniasis” Comprehensive Inorganic Chemistry II (2nd edition), Volume 3- Bioinorganic Fundamentals and Applications: Metals in Natural Living Systems and Metals in Toxicology and Medicine, 975-986, Elsevier, 2013. doi: 10.1016/B978-0-08-097774-4.00339-9. (invited)

  10. Xiong J.Y., Cheng G., Qiu F., Wang R.M., Sun H.Z., Chen R. (2013) “Tunable BiOCl hierarchical nanostructures for high-efficient photocatalysis under visible light irradiationChemical Engineering Journal, 220, 228-236. doi: 10.1016/j.cej.2013.01.033.

  11. Hu L.G.*, Wang Y.C., He B., Jiang G.B., Sun H.Z.* (2013) “Metallomics in environmental and health related research: current status and perspectivesChinese Science Bulletin, 58(2), 169-176. doi: 10.1007/s11434-012-5496-1.

  12. Cheng T.F., Xia W., Wang P.W., Huang F.J. Wang J.W., Sun H.Z.* (2013) "Histidine-rich proteins in prokaryotes: metal homeostasis and environmental habitat-related occurrenceMetallomics, 5, 1423-1429. doi: 10.1039/C3MT00059A.


  1. Yang N., Zhang H.M., Hao Q., Sun H.Z.* (2012) “Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobeScientific Reports, 2, 999; doi: 10.1038/srep00999.

  2. Wang X.H., Li H.Y., Du X.B., Harris J., Guo Z.J., Sun H.Z.* (2012) “Activation of carboplatin and nedaplatin by the N-terminus of human copper transporter 1 (hCTR1)Chemical Science, 3(11), 3206-3215. doi: 10.1039/C2SC20738A.

  3. Xia W., Li H.Y., Yang X.M., Wong K.B., Sun H.Z.* (2012) “Metallo-GTPase HypB from Helicobacter pylori and its interaction with nickel chaperone protein HypAJournal of Biological Chemistry, 287(9), 6753-6763. doi: 10.1074/jbc.M111.287581.                         

  4. Cheng T.F., Li H.Y., Xia W., Sun H.Z.* (2012) “Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturationJournal of Biological Inorganic Chemistry, 17(3), 331-343. doi: 10.1007/s00775-011-0855-y.                                                      

  5. Qin F., Li G.F., Xiao H., Lu Z., Sun H.Z., Chen R. (2012) “Large-scale synthesis of bismuth hollow nanospheres for highly efficient Cr(VI) removalDalton Transactions, 41(37), 11263-11266. doi : 10.1039/C2DT31021J.

  6. Qin F., Li G.F., Wang R.M., Wu J.L., Sun H.Z., Chen R. (2012) “Template-free fabrication of Bi2O3 and (BiO)2CO3 nanotubes and their application in water treatmentChemistry, a European Journal, 18(51), 16491-16497. doi: 10.1002/chem.201201989.

  7. Du X.B., Wang X.H., Li H.Y., Sun H.Z.* (2012) “Comparison between copper and cisplatin transport mediated by human copper transporter 1 (hCtr1)Metallomics, 4(7), 679 -685. doi: 10.1039/C2MT20021J.

  8. Li G.F., Qin F., Yang H., Lu Z., Sun H.Z., Chen R. (2012) “Facile microwave synthesis of 3D flowerlike BiOBr nanostructures and their excellent CrVI removal capacityEuropean Journal of Inorganic Chemistry, 2508-2513. doi: 10.1002/ejic.201101427.

  9. Xu Z.H., Jin J., Siu L.K.S., Yao H., Sze J., Sun H.Z., Kung H.F., Poon W.S., Ng S.S.M., Lin M.C. (2012) “Folic acid conjugated mPEG-PEI600 as an efficient non-viral vector for targeted nucleic acid deliveryInternational Journal of Pharmaceutics, 426(1-2), 182-192. doi: 10.1016/j.ijpharm.2012.01.009.

  10. Shan Y., Pan Q., Liu J., Huang F.J., Sun H.Z., Nishino K., Yan A. (2012) “Covalently linking the Escherichia coli global anaerobic regulator FNR in tandem allows it to function as an oxygen stable dimerBiochemical and Biophysical Research Communications, 419(1), 43-48. doi: 10.1016/j.bbrc.2012.01.121.

  11. Li H.Y., Sun H.Z.* (2012) “Recent advances in bioinorganic chemistry of bismuth”. Current Opinion in Chemical Biology, 16(1-2), 74-83. doi: 10.1016/j.cbpa.2012.01.006.

  12. Tsang C.N., Bianga J., Sun H.Z., Szpunar  J., Lobinski R. (2012) “Probing of bismuth antiulcer drug targets in H. pylori by laser ablation- inductively coupled plasma mass spectrometry”  Metallomics, 4(3), 277-283. doi: 10.1039/C2MT00169A.

  13. Li H.Y., Sun H.Z. (2012) “NMR studies of metalloproteinsTopics in Current Chemistry (NMR of proteins and small biomolecules), 326, 69-98. doi: 10.1007/128_2011_214.


  1. Fong Y.H., Wong H.C., Chuck C.P., Chen Y.W., Sun H.Z., Wong K.B. (2011) “Assembly of the preactivation complex for urease maturation in Helicobacter pylori: crystal structure of the UreF/UreH complexJournal of Biological Chemistry, 286(50), 43241-43249. doi: 10.1074/jbc.M111.296830. (Paper of the Week)  

  2. Li G., Ding Y., Zhang Y., Lu Z., Sun H.Z., Chen R. (2011) “Microwave synthesis of BiPO4 nanostructures and their morphology-dependent photocatalytic performancesJournal of Colloid and Interface Science, 363 (2), 497-503. doi: 10.1016/j.jcis.2011.07.090.

  3. Ge R.G., Sun X.S., Wang D. X., Zhou Q.L., Sun H.Z. (2011) “Histidine-rich protein Hpn from Helicobacter pylori forms amyloid-like fibrils in vitro and inhibits the proliferation of gastric epithelial AGS cellsBiochimica et Biophysica Acta - Molecular Cell Research, 1813(8), 1422-1427. doi: 10.1016/j.bbamcr.2011.04.005.

  4. Zeng Y.B., Yang N., Sun H.Z.* (2011) “Metal-binding properties of histidine-rich protein, Hpn-likeChemistry, a European Journal, 17(21), 5852-5860. doi: 10.1002/chem.201100279.  (Inside Cover)

  5. Tsang C.N., Ho K.S., Sun H.Z.*, Chan W.T.* (2011) “Tracking bismuth drug uptake in single Helicobacter pylori cellsJournal of the American Chemical Society, 133(19), 7355-7357. doi: 10.1021/ja2013278.

  6. Wang X.H., Du X.B., Li H.Y., Chan D.S.B., Sun H.Z.* (2011) “The effect of the extracellular domain of human copper transporter (hCTR1) on cisplatin activationAngewandte Chemie International Edition, 50(12), 2706-2711. doi: 10.1002/anie.201006739. (Frontispiece)

  7. Yang N., Sun H.Z.* (2011) “Bismuth: environmental pollution and health effects” in Nriagu JO (ed.) Encyclopedia of Environmental Health, Volume 1, 414-420 Burlington:  Elsevier doi:  10.1016/B978-0-444-52272-6.00374-3. (invited).


  1. Yang N., An Y., Cai J.W., Hu L.H., Zeng Y.B., Mao Z.W., Chen G.H., Sun H.Z.* (2010) “Polymeric architectures of bismuth citrate based on dimeric building blocks” Science in China- Chemistry, 53(10), 2152-2158. doi: 10.1007/s11426-010-4113-x.

  2. Sun X.S, Ge R.G., Zhang D.M., Sun H.Z., He Q.Y. (2010). “Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenesJournal of Biological Inorganic Chemistry, 15(8), 1265-1273. doi: 10.1007/s00775-010-0684-4.

  3. Sun H.Z.*, Chai Z.F. (2010) “Metallomics: an integrated science for metals in biology and medicineAnnual Reports on the Progress of Chemistry, Section A: Inorganic Chemistry, 106, 20-38. doi: 10.1039/B920672H. (Featured on the cover of 2010 issue)

  4. Cun S.J., Sun H.Z.* (2010) “A zinc-binding site by negative selection induces metallodrug susceptibility of an essential chaperonin”, Proceedings of the National Academy of Sciences, USA, 107(11), 4943-4948. doi: 10.1073/pnas.0913970107.

  5. Tian Y., Hou X., Wen L., Guo W., Song Y., Sun H.Z., Wang Y., Jiang L., Zhu D. (2010) “A biomimetic zinc activated ion channelChemical Communications, 46(10), 1682-1684. doi: 10.1039/B918006K.

  6. Ge R.G., Chu I.K., Sun H.Z.* (2010) “Chapter 9 - Nuclear-based metallomics in metal-based drugs” in Advanced nuclear analytical techniques for metallomics and metalloproteomics (Edited by C.Y. Chen, Z.F. Chai, YX Gao), Royal Society of Chemistry, 265-298. doi: 10.1039/9781847559913-00265.

  7. Chen R., Cheng G., Man S.H., Wu J.L., Lu Z., Che C.-M., Sun H.Z. (2010) “Bismuth subcarbonate nanoparticles fabricated by water-in-oil micromulsion-assisted hydrothermal process exhibit anti-Helicobacter pylori propertiesMaterials Research Bulletin, 45(5), 654-658. doi: j.materresbull.2009.12.035.

  8. Li H.Y.*, Sze K.H., Fung K.L., Sun H.Z.* (2010)“Validation of inter-helical orientation of the sterile-alpha-motif domain of the deleted in liver cancer 2 (DLC2-SAM) by 15N-1H residual dipolar couplingsChinese Journal of Magnetic Resonance, 27(4), 585-596. (invited)

  9. Lam M.P.Y., Siu S.O., Lau E., Mao X.L., Sun H.Z., Chiu P.C.N., Yeung W.S.B., Cox D.M., Chu I.K. (2010) "Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization" Analytical and Bioanalytical  Chemistry, 398(2), 791-804. doi: 10.1007/s00216-010-3991-2.

  10. Sun H.Z., Lam K.M., Fung Y.S. (2010) "A new capillary electrophoresis buffer for determining organic and inorganic anions in electroplating bath with surfactant additivesJournal of Chromatography. A, 1217(19), 3244-3250. doi: 10.1016/j.chroma.2010.01.011.