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Book Pages

Publications (2016-2023)

2022

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  1. Zhou Y., Li H.Y., Sun H.Z.* "Metalloproteoics for biomedical research: methodology and applications". Annual Review of Biochemistry (Editor: Kornberg, R.), doi: 10.1146/annurev-biochem-040320-104628
  2. Zhang Q.§, Wang R.M.§, Wang M.J., Liu C.J., Koohi-Moghadam M., Wang H.B., Ho P.L., Li H.Y., Sun H.Z.* "Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver". Proceedings of the National Academy of Sciences USA, 119 (11) e2119417119, doi: 10.1073/pnas.2119417119
  3. Li H.Y., Sun H.Z.* "A hydroxide lock for metallo-β-lactamases" . Nature Chemistry, 14, 6-8, doi: 10.1038/s41557-021-00871-3
  4. Wang R.M.§, Chan J.F.W.§, Wang S.Y.§, Li H.Y., Zhao J.J., Ip T.K.Y., Zuo J.Z., Yuen K.Y., Yuan S.F., Sun H.Z.* "Orally administrated bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy". Chemical Science, 13, 2238-2248, doi: 10.1039/D1SC04515F.

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2021

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  1. Yan X.T.,  Zhou Y., Jiang G.B., Li H.Y., Sun H.Z.* "Metallomics and metalloproteomics", in Comprehensive Inorganic Chemistry III (Editor: Pecoraro, V.P., Guo, Z.J.), accepted

  2. Zhou Y., Tse E.W.C., Leung R., Cheung E., Li H.Y., Sun H.Z.* "Multiplex single-cell analysis of cancer cells enables unbiased uncovering subsets associated with cancer relapse: heterogeneity of multidrug resistance in precursor B-ALL", ChemMedChem, 16, doi: /10.1002/cmdc.202100638.

  3. Wang C., Li X., Cheng T.F., Sun H.Z., Jin L.J.* "Eradication of porphyromonas gingivalis persisters through colloidal bismuth subcitrate synergistically combined with metronidazole", Frontiers in Microbiology, 12, 748121, doi: 10.3389/fmicb.2021.748121.

  4. Li Y.F.*, Sun H.Z. "Metallomics in multidisciplinary research and the analytical advances", Atomic Spectroscopy, 42(5), 227-230, doi: 10.46770/AS.2021.108.

  5. Zhao J.T., Wang L.M., Cui L.W., Sun H.Z.*, Gao Y.X., Li Y.F.* "Metallomics for the screening of COVID-19 and metallodrug development", Atomic Spectrscopy, 42(5), 231-237, doi: 10.46770/AS.2021.805. 

  6. Griffith D.§, Li H.Y.§, Werrett M.W., Andrews P., Sun H.Z.* "Medicinal chemistry and biomedical applications of bismuth-based compounds", Chemical Society Review, 50(21), 12037-12069, doi: 10.1039/D0CS00031K.

  7. Hu X.Q.§, Li H.Y.§, Ip T.K.Y., Cheung Y.F., Koohi-Moghadam M., Wang H.B., Yang X.M., Tritton D. N., Wang Y.C., Wang Y., Wang R.M., Ng K.M., Naranmandura H., Tse E.W.C., Sun H.Z.* "Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin".  Chemical Science, 12(32), 10893-10900, doi: 10.1039/D1SC03119H

  8. Maimaitiyiming Y., Wang Q.Q., Yang C., Ogra Y., Lou Y.J., Smith C.A., Hussain L., Shao Y.M., Lin J.B., Liu J.F., Wang L.F., Zhu Y., Lou H.Y., Huang Y., Li X.X., Chang K.J., Chen H. Li H.Y., Huang, Y., Tse, E., Sun, J., Bu, N., Chiou, S.H., Zhang, E.F, Hua, H.Y., Ma, L.Y., Huang, P., Ge, M.H., Cao F.L., Cheng X.D., Sun H.Z., Zhou J., Vasliou V., Xu P., Jin J., Bjorklund M., Zhu H.H., Hsu C.H., Naranmandura H.* "Hyperthermia selectively destabilizes ongoneic fusion proteins". Blood Cancer Discovery, 2(4), 388-401, doi: 10.1158/2643-3230.BCD-20-0188. 

  9. Wang H.B., Wang M.J., Xu X.H., Gao P., Xu Z.L., Zhang Q., Li H.Y., Yan A.X., Kao R.Y. -T., Sun H.Z.* “Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance”. Nature Communications, 12, 3331, doi: 10.1038/s41467-021-23659-y.

  10. Yuan S.F., Yin X., Meng X.Z., Chan J.F.W., Ye Z.W., Riva L., Pache L., Chan C.C.Y., Lai P.M., Chan C.C.S., Poon V.K.M., Lee A. C.Y., Matsunaga N., Pu Y., Yuen C.K., Cao J.L., Liang R.H., Tang K.M., Sheng L., Du Y.S., Xu W., Lau C.Y., Sit K.Y., Au W.K., Wang R.M., Zhang Y.Y., Tang Y.D., Clausen T.M., Pihl J., Oh J., Sze K.H., Zhang A.J.X., Chu H., Kok K-H., Wang D., Cai X.H., Esko J.D., Hung I.F.N., Li R.A., Chen H.L., Sun H.Z., Jin D.Y., Sun R., Chanda S.K., Yuen K.Y.* (2021) “Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters”. Nature, 593, 418-423. doi: 10.1038/s41586-021-03431-4. 

  11. Xu X.H.§, Wang H.B.§, Li H.Y., Sun H.Z.* (2021) “Dynamic and temporal transcriptomic analysis reveals ferroptosis-mediated anti-leukemia activity of S-dimethylarsino-glutathione: insights into novel therapeutic strategy” CCS Chemistry, 3, 1089-1100. doi: 10.31635/ccschem.021.202000685.

  12. Tse E.C.M.*, Sun H.Z.* (2020) Book review for “Transition Metals and Sulfur –A Strong Relationship for Life”, Metal Ions in Life Sciences, vol. 20, Zeitschrift für Naturforschung C, 76(5-6)c, 257-259, doi: 10.1515/znc-2020-0252.

  13. Zhou Y., Ip T.K.Y., Zhang Q., Li H.Y., Sun H.Z.* (2020) “Metal complexes as drugs and chemotherapeutic agents” in Comprehensive Coordination Chemistry III (Volume 9: “Applications of Coordination Chemistry”), 680-705, Elsevier. doi: 10.1016/B978-0-08-102688-5.00018-0.

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​2020​

  1. Wang H.B.*, Yang X.M., Wang M.J., Xu X.H., Hu M.L, Yan A.X., Hao Q., Li H.Y., Sun H.Z.* (2020) “Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm” Chemical Science, 11(43), 11714-11719. doi: 10.1039/D0SC04151C.

  2. Yuan S.F.§, Wang R.M.§, Chan J.F.W.§, Zhang A.J., Cheng T.F., Chik K.K.H., Ye Z.W., Wang S.Y., Lee A.C., Jin L.J., Li H.Y., Jin D.Y., Yuen K.Y.*, Sun H.Z.* (2020) “Metallodrug ranitidine bismuth citrate suppress SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters” Nature Microbiology, 5(11), 1439-1448. doi: 10.1038/s41564-020-00802-x.

  3. Sun H.Z. §*, Zhang Q.§, Wang R.M.§*, Wang H.B., Wong Y.T., Wang M.J., Hao Q., Yan A.X., Kao R.Y.T., Ho P.L., Li H.Y. (2020) “Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin” Nature Communications, 11(1), 5263, doi: 10.1038/s41467-020-18939-y.

  4. Wang R.M., Wang S.Y., Chan S., Zuo Z., Chan G.C.F., Li H.Y., Sun H.Z.* (2020) “Bismuth porphyrin antagonizes cisplatin-induced nephrotoxicity via inactivating caspase-dependent apoptotic pathway” iScience, 23(5), 101054. doi: 10.1016/j.isci.2020.101054.

  5. Tao X., Zhang Z.M., Zhang X., Li H.Y., Sun H.Z.*, Mao Z.W., Xia W.* (2020) “Structural insight into the substrate gating mechanism by Staphylococcus aureus aldehyde dehydrogenase” CCS Chemistry, 2(3), 946-954. doi: 10.31635/ccschem.020.202000219.

  6. Xu X.H., Wang H.B., Li H.Y., Sun H.Z.* (2020) “Metalloproteomic approaches for matching metals to proteins: The power of inductively coupled plasma mass spectrometry (ICP-MS)” Chemistry Letter, 49(6), 697-704. doi: 10.1246/cl.200155. (invited, featured on the front cover)

  7. Kanatzidis M., Sun H.Z., Dehnen S.* (2020) “Bismuth- the magic element” Inorganic Chemistry, 2020, 59(6) 3341-3343. doi: 10.1021/acs.inorgchem.0c00222. (editorial)

  8. Wang H.B., Zhou Y., Xu X.H., Li H.Y., Sun H.Z.* (2020) “Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: mechanism-driven new therapy development” Current Opinion in Chemical Biology, 55, 171-179. doi: 10.1016/j.cbpa.2020.02.006. (invited)

  9. Wang R.M., Li H.Y., Ip T.K.Y., Sun H.Z.* (2020) “Chapter 6 − Bismuth drugs as antimicrobial agents” Advances in Inorganic Chemistry, 75, 183-205. doi: 10.1016/bs.adioch.2019.10.011.

  10. Jiang N., Wang Y.L., Chan K.C., Sun H.Z.*, Li G.J.* (2020) “Additive manufactured graphene coating with synergistic photothermal and superhydrophobic effects for bactericidal applications” Global Challenges, 4(1), 1900054. doi: 10.1002/gch2.201900054.

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2019

  1. Koohi-Moghadam M., Wang H.B., Wang Y.C., Yang, X.M., Li H.Y., Wang J.W.*, Sun H.Z.* (2019) “Predicting disease-associated mutation of metal binding sites of a protein using a deep learning approach” Nature Machine Intelligence, 1(12), 561-567. doi: 10.1038/s42256-019-0119-z. (Highlighted as a ‘news&views’ entitled “DEEP LEARNING IN MEDICINE Predicting cracks in metalloproteins”, 1(12), 553-554)

  2. Xu Z.L., Wang P.C., Wang H.B., Hang Z., Au-Yeung H.Y., Hirayama T. Sun H.Z., Yan A.X. (2019) “Zinc excess leads to an increased cellular demand for iron and decreased tolerance to copper in Escherichia coli” Journal of Biological Chemistry, 294(45), 16978-16991. doi: 10.1074/jbc.RA119.010023.

  3. Xu, X.H., Wang H.B., Li, H.Y., Hu X.Q., Zhang Y., Guan X.Y., Toy P.H., Sun H.Z.* (2019) “S-dimethylarsino-glutathione (darinaparsin®) targets Histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells” Chemical Communications, 55(87), 13120-13123. doi: 10.1039/C9CC07605K.

  4. Jiang N., Li H., Sun H.Z.* (2019) “Recognition of proteins by metal chelation-based fluorescent probes in cells” Frontiers in Chemistry, 7, 560. doi: 10.3389/fchem.2019.00560 (invited)

  5. Wang Y.C., Li H.Y., Sun H.Z.* (2019) “Metalloproteomics for unveiling the mechanism of action of metallodrugs and their candidates” Inorganic Chemistry, 58(20), 13673-13685. doi: 10.1021/acs.inorgchem.9b01199.  (featured in the Supplementary cover)

  6. Wang H.B., Wang M.J., Yang X.M., Xu X.H., Hu M.L., Yan A.X., Hao Q., Lobinski R., Li H.Y., Sun H.Z.* (2019) “Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in E. coli”, Chemical Science, 10(30), 9193-7199.  doi: 10.1039/C9SC02032B.

  7. Wang Y.C., Han B.J., Xie Y.X., Wang H.B., Wang R.M., Xia W., Li H.Y., Sun H.Z.* (2019) “Combination of gallium(III) with acetate for combating antibiotic resistant Pseudomonas aeruginosai”, Chemical Science, 10(24), 6099-6106. doi: 10.1039/C9SC01480B. (ChemSci Pick of the Week  and HOT Article)

  8. Wang R.M., Li H.Y., Sun H.Z.* (2019) “Bismuth: environmental pollution and health effects” in Encyclopedia of Environmental Health, 2nd edition, edited by Nriagu J., Elsevier. 415-423. doi: 10.1016/B978-0-12-409548-9.11870-6. (invited contribution)

  9. Cheng T.F., Lai Y.T., Wang Y., Jiang N., Li H.Y., Sun H.Z.*, Jin L.J.* (2019) “Bismuth drugs tackle Porphyromonas gingivalis and attune cytokine response in human cells”, Metallomics, 11(7), 1207-1218. doi: 10.1039/c9mt00085b.

  10. Yang Y., Chang C.C., Lai Y.Z., Yang X.M., Sun H.Z.*, Li H.Y.* (2019) “Green fluorescent probe for imaging His6-tagged protein inside living cells” ACS Sensors, 4(5), 1190-1196. doi: 10.1021/acssensors.8b01128.

  11. Wang H.B., Yan A.X., Liu Z.G., Yang X.M., Xu Z.L., Wang M.J., Hu M.L., Wang Y.C., Wang R.M., Koohi-Moghadam M., Hu L.G., Xia W., Hao Q., Tang H.R., Wang Y.L., Li H.Y., Sun H.Z.* (2019) “Deciphering molecular mechanism of silver allows enhancing its antimicrobial efficacy”, PLOS Biology, 17(6): e3000292. doi: 10.1371/journal.pbio.3000292.

  12. Guo Y., Guan C.J., Wan H.Y., Zhang Z.G, Li H.Y., Sun H.Z., Xia W.* (2019) “Inactivation of NikR from Helicobacter pylori by a bismuth drug”, Journal of Inorganic Biochemistry, 196, 110685. doi: 10.1016/j.jinorgbio.2019.03.025.

  13. Zhang Z.M, Huang Q., Xu D., Tao X., Song G.B., Zheng P., Li H.Y., Sun H.Z., Xia W.* (2019) “The unique trimeric assembly of virulence factor HtrA from Helicobacter pylori via N-terminus domain-swapping”, Journal of Biological Chemistry, 294(20), 7990-8000. doi: 10.1074/jbc.RA119.007387. 

  14. Chan S., Wang R.M., Man K., Nicholls J., Li H.Y., Sun H.Z.*, Chan G.C.* (2019) “A novel synthetic compound, bismuth zinc citrate, could potentially reduce cisplatin-induced toxicity without compromising the anticancer effect through enhanced expression of antioxidant protein” Translational Oncology, 2019, 12(5), 788-799. doi: 10.1016/j.tranon.2019.02.003.

  15. Koohi-Moghadam M., Borad M., Tran N., Swanson K, Boardman L., Sun H.Z.*, Wang J.W.* (2019) “MetaMarker: a de novo pipeline for discovering novel metagenomic biomarkers” Bioinformatics, 35(19), 3812-3814. doi: 10.1093/bioinformatics/btz123.

  16. Li H.Y., Wang R.M., Sun H.Z.* (2019) “Systems approaches for unveiling the mechanism of action of bismuth drugs: new medicinal applications beyond Helicobacter pylori infection” Accounts of Chemical Research, 52(1), 216-227. doi: 10.1021/acs.accounts.8b00439.

  17. Cheng Y.H., Cheung Y.F., Tam T.S.C., Lok C.N., Sun H.Z., Ng K.M.* (2019) “Plasmonic metal nanoparticles as efficient mass tags for ion signal amplification and ultrasensitive detection of protein markers” Analytical Chimica Acta, 1055, 1-6. doi: 10.1016/j.aca.2018.12.057. (selected as “featured article”)

  18. Yang X.L., Liu X., Wu Q.Q., Lv X., Li B., Sun H.Z., Xu W.F., Liao X.L.* (2019) "Dopamine-assisted immobilization of peptide arginine-glycine-aspartic acid to enhance the cellular performances of MC3T3-E1 cells of carbon-carbon composites", Journal of Biomaterials Applications, 34(2), 284-296. doi: 10.1177/0885328219845962.

  19. Yang L.M., Xing S.Y., Sun H.Z., Miao C.L., Li M., Lv P.M., Wang Z.M., Yuan Z.H.* (2019) "Citric-acid-induced mesoporous SAPO-11 loaded with highly dispersed nickel for enhanced hydroisomerization of oleic acid to iso-alkanes", Fuel Processing Technology, 187, 52-62. doi: 10.1016/j.fuproc.2019.01.008.

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2018

  1. Prinz J., Koohi-Moghadam M., Sun H.Z., Kocher J.A., Wang J.W. (2018) “Novel neural network approach to predict drug-target interactions based on drug side effects and genome-wide association studies” Human Heredity, 83(2), 79-91. doi: 10.1159/000492574.

  2. Zhou Y., Wang H.B., Tse E., Li H.Y., Sun H.Z.* (2018) “Cell cycle-dependent uptake and cytotoxicity of arsenic-based drugs in single Leukemia cells” Analytical Chemistry, 90(17), 10465-10471. doi: 10.1021/acs.analchem.8b02444.

  3. Han B.J., Zhang Z., Xie Y.X, Hu X.Q., Wang H.B., Xia W., Wang Y.L, Li H.Y., Wang Y.C.*, Sun H.Z.* (2018) “Multi-omics and temporal dynamics profiling reveals disrupted central metabolism in Helicobacter pylori on bismuth treatment” Chemical Science, 9(38), 7488-7497. doi: 10.1039/C8SC01668B. (Chemical Science 2018 HOT article, highlighted in ChemistryWorld 2018, September issue, 44-45)

  4. Curtin J.P.*, Wang M.J., Cheng T.F., L.J. Jin, Sun H.Z. (2018) “The role of citrate, lactate and transferrin in determining titanium release from surgical devices into human serum” Journal of Biological Inorganic Chemistry, 23(3), 471-480. doi: 10.1007/s00775-018-1557-5.

  5. Wang R.M., Lai T.P., Gao P., Zhang H.M., Ho P.L, Ma G.X., Woo P.C.Y., Kao Y.T., Li H.Y., Sun H.Z. (2018) “Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors”, Nature Communications, 9(1), 439. doi: 10.1038/s41467-018-02828-6. 

  6. Yang X.M., Koohi-Moghadam M., Wang R.M., Chang Y.Y., Woo P.C.Y., Wang J.W., Li H.Y.*, Sun H.Z.* (2018) “Metallochaperone UreG serves as a new target for design of urease inhibitor: a novel strategy for development of antimicrobials” PLoS Biology, 16(1), e2003887. doi: 10.1371/journal.pbio.2003887.

  7. Jiang N., Cheng T.F., Wang M.J., Chan, G.C.F., Jin L.J., Li, H.Y., Sun H.Z.* (2018) “Tracking iron-associated proteomes in pathogens by a fluorescence approach”, Metallomics, 10(1), 77-82. doi: 10.1039/C7MT00275K.

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2017

  1. He X.J., Liao X.W., Li H Y., Xia W., Sun H.Z.* (2017) “Bismuth-induced inactivation of ferric uptake regulator from Helicobacter pylori” Inorganic Chemistry, 56(24), 15041-15048. doi: 10.1021/acs.inorgchem.7b02380.

  2. Liao X.W., Yang F., Li H.Y. Xia W.*, Sun H.Z.* (2017) “Targeting the thioredoxin reductase-thioredoxin system from Staphylococcus aureus by silver ions” Inorganic Chemistry, 56(24), 14823–14830. doi: 10.1021/acs.inorgchem.7b01904.

  3. Liao X.W., Yang F., Wang R.M., He X.J., Li H.Y., Kao R.Y.T., Xia, W.*, Sun H.Z.* (2017) “Identification of catabolite control protein A (ccpA) from Staphylococcus aureus as a target of silver ions” Chemical Science, 8(12), 8061-8066. doi: 10.1039/C7SC02251D.

  4. Wang Y.C., Hu L.G., Xu F., Quan Q., Lai Y.T., Xia W., Yang Y., Chang Y.Y., Yang X.M., Chai Z.F., Wang J.W., Chu I.K., Li H.Y., Sun H.Z.* (2017) “Integrative approach for analysis of proteome-wide response to bismuth drugs in Helicobacter pylori” Chemical Science, 8(6), 4626-4633. doi: 10.1039/C7SC00766C.

  5. Chang Y.Y., Cheng T.F., Yang X.M., Jin L.J., Sun H.Z.* (2017) “Functional disruption of peroxiredoxins by bismuth drugs attenuates Helicobacter pylori survival”, Journal of Biological Inorganic Chemistry, 22(5), 673-683. doi: 10.1007/s00775-017-1452-5.

  6. Zhou Y., Li H., Sun H.Z.* (2017) “Cytotoxicity of arsenic trioxide in single leukemia cells by time-resolved ICP-MS together with lanthanide-tags” Chemical Communications, 53(20), 2970-2973. doi: 10.1039/C7CC00143F.

  7. Lai Y.Z., Yang Y., Hu L.G., Cheng, T.F., Chang Y.Y., Koohi-Moghadam M., Wang Y.C., Xia J., Wang J.W., Li H.Y., Sun H.Z.* (2017) “Integration of fluorescent imaging with proteomics enables visualization and identification of endogenous metallo-proteomes in live cells” Metallomics, 9(1), 38-47. doi: 10.1039/C6MT00169F.

  8. Chao A., Jiang N., Yang Y., Li H.Y., Sun H.Z.* (2017) “A Ni-NTA-based red fluorescence probe for proteins labelling in live cells” Journal of Material Chemistry B, 2017, 5(6), 1166-1173. doi: 10.1039/C6TB02848A.

  9. Wang Y.C., Wang H.B., Li H.Y., Sun H.Z.* (2017) “Application of metallomics and metalloproteomics for understanding the molecular mechanisms of action of metal-based drugs” in “Essential and non-essential metals: carcinogenesis, prevention and chemotherapy” edited by Zelikoff J., Mudipalli A. Sr., Springer, Gewerbestrasse 11, 6330 Cham, Switzerland, 199-222. doi: 10.1007/978-3-319-55448-8_9.

  10. Chang Y.Y., Li H.Y., Sun H.Z.* (2017) “Chapter 9: Immobilized metal affinity chromatography (IMAC) for metalloproteomics and phosphoproteomics” in “Interactions of Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells” edited by Lo K.K.W., Elsevier, 329-353. doi: 10.1016/B978-0-12-803814-7.00009-5.

  11. Xia W., Li H.Y., Sun H.Z.* (2017) “Chapter 14: Nickel metallochaperones: structure, function and nickel-binding” in The Biochemistry of Nickel edited by Zamble D., Henryk K., Magdalena R-Z, The Royal Society of Chemistry, Cambridge, UK, 284-305. doi: 10.1039/9781788010580-00284.

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2016

  1. Cheng T.F., Li H.Y. Jin L.J., Sun H.Z.* (2016) “Exploration into the nickel ‘microcosmos’ in prokaryotes” Coordination Chemistry Reviews, 311, 24-37. doi: 10.1016/j.ccr.2015.12.007.

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